A mathematical framework for the selection of an optimal set of peptides for epitope-based vaccines.
Epitope-based vaccines (EVs) have a wide range of applications: from therapeutic to prophylactic approaches, from infectious diseases to cancer.The development of an EV is based on the knowledge of target-specific antigens from which immunogenic peptides, so-called epitopes, are derived.Such epitopes form the key components of the EV.Due to regulat